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AI如何助力脑科学产业化

摘要: 除了广受关注的阿兹海默症外,癫痫也是脑科学研究一个很好的模型。

图片来源@全景视觉

tupianlaiyuan@quanjingshijue

wenshuvbdongmaiwang

naokexue,beirenweishirenleikexuezuihoudeqianyan。suirandanaoshitizhiqijuyurenleibudadenaodainei,danshiyanjiudanaobingbubiyanjiuhaohandeyuzhoujiandan。 

zaihenduorenhaijinjinbanaokexueshiweikeyanguiguanshangnanyiqijidemingzhushi,yijingyoujishiyimeijindezijinliurunaokexueyanjiulingyu,zheixieyazhuzhebushibieren,ershigeguozhengfu。

zi2013nianmeiguokaiqinaojihuayilai,meiguo、oumeng、riben、aodaliya、hanguodengguojiahediquxiangjituichulegezidenaokexueyanjiujihua,naokexueyuleinaoyanjiuyichengweidangqianguojikejiqianyanderedianlingyu,beigeguoshiweiweilaixindejingjizengzhangdianheyinlingxinkejidebiangeyinqing。

dandaomuqianweizhi,renleiguanyudanaodeyanjiumuqianhaixiangdangcuqian。niuyuedaxueyixueyuanshenjingkexuejiaoshoudejieerji·busaji(györgy buzsáki)zaixinshu《youneierwaikandanao》zhongxiedao: “caipiaopingtaizhengbuduanqudejinzhan,danwentiyiranfeichangjishou。”

mianduinaokexueyanjiu,caipiaopingtaijiujingchuyulimingqiandeheianhaishiganggangtaruyongye,yiqiehaibudeerzhi。danzhishaoyouyidianshiguangmingde, muqianyongyudanaoyanjiudejishuzhengzaimohuchuantongdexuekebianjie,rengongzhineng、yunjisuan、dashujudengjisuanjixuezhengzaiyushengwuxuejiehetansuodanao,zheixiexinbianliangdejiaruhuoxunengweicaipiaopingtaidailaixinfaxian。

动脉网通过梳理发现,在脑科学领域,除了吸引了众多关注的阿兹海默症,在神经系统疾病中,癫痫是脑科学研究一个很好的模型,尤其是在难治性癫痫中,通过脑部深电极(SEEG)获得的“深脑信号”为脑科学研究提供了大量稀缺的脑部信号。显然,在脑电数据大规模产生的时代,依靠人工的数据处理方式已经无法应对,AI的介入带来了新的数据发掘方法。

qishizheibingbushiaitongguodianxianyanjiunaokexuelingyudeweiyiqiekou, zaikeyanzhiwai,ai+naodianzaishangyehuahechanyehuafangmian,younaxieqierulujing?cunzaiduodadexiangxiangkongjian?dongmaiwangjinxingleshuli。

国内脑电研究的一体两翼如何展开

naokexuefazhanxianzaidejieduan,xiangdangyuwulixuehehuaxuezai20shijichuqidechujing,kexuejiamenzaihenduoxifenlingyuqudetupo,danshizhongdadelijiehetuposhangweichuxian。muqiannaokexuezhongzuiguanjiandewenti,shirenleiduinaodegezhonggongnengheshenjingwangluogongzuoyuanliderenzhifeichangculve,zhinengdazhilijierenleinaoquhegongnengdeguanxi,dangengduodexijiebingbuqingchu。

naokexuededashashangweijiancheng,zailuoshidashajizuofangmian,caipiaopingtaixuyaogengjichudenaokexuelilun。zheiyehecaipiaopingtaiguonaojihuadezhongdianxiangfu。2019nianqianhou,jingguozhangdawunianduoshijiandeyunniang,zhongguozaikexuejiexingcheng“yitiliangyi”naojihuayanjiufangxiangdejichugongshi。

zhongguonaojihua“yitiliangyi”guanzhu“naokexuedejibenwenti;naojibingdezhenduanzhiliao;naoqifaderengongzhineng”。

“yiti”ji“renzhinao”,guanzhuhelijierenleidanaoderenzhigongnengshizenmelaide。hexinshirenzhinaoqujiegouhegongnengshenjingwangluodeshizhi,changshichanmingdanaoruhegongzuo。

正如中国脑计划的领军者和倡导者蒲慕明院士所描述的“彩票平台看到计算机,要分析它的功能就必须知道计算机的结构,对于大脑的功能彩票平台必须要知道大脑的网络结构,这就叫做‘全脑介观神经联接图谱’,也是彩票平台这个大计划的关键部分”。

彩票平台liangyi,zezhixiang“baohunao”he“chuangzaonao”liangdazhugongfangxiang。

其中,“保护脑”主要是更好地诊断和治疗各类重大脑疾病,包括阿尔茨海默症、癫痫、帕金森、抑郁症等疾病,在神经系统疾病这条赛道上,将有机会诞生千亿独角兽。

“chuangzaonao”zhuyaoshixianleinaorengongzhinengdeyanjiuyukaifa,hexinzhanlvemubiaoshikaifafangnaojisuanji,jiangyouliangbufenzucheng:yishifazhannaoxingqijianhejiegou;ershinaoxingxinxichanshenghechulixitongdeshejihekaifa。

中国脑计划的巨大价值在于其在未来五到十年的持续实施,会全力推动人工智能与脑科学的深度融合发展,其研究成果,将会极大的促进类脑人工智能技术的发展,这一领域的研究突破,将引领新一轮的科技革命。

癫痫成为脑科学研究的先导领域

彩票平台zaiyitiliangyizhong,nayilingyuyanjiujiaoweipoqie?daanwuyishiduizhongdanaobujibingjinxingzhenduanhezhiliao。

jushijieweishengzuzhidetongji,baokuoaercihaimo、pajinsen、dianxian、jingshenfenlie、yiyuzhengzaineidegezhongshenjingleihejingshenleijibingzaineidenaoxiangguanjibing,shisuoyoujibinglishehuifudanzuidadejibing,zhandao28%yishang,bingyichaoguoxinxueguan、aizheng,chengweiyingxiangrenleishengcunzhiliangdeshouyaojibing。

彩票平台yinci,zhongdanaojibingdezhenduan、zhiliaoyuganyu,jiangchengweigeguonaojihuazhong,zuijuxianshiyiyiyuweilaijiazhidexiandaolingyu。

zhongsuozhouzhi,renleidanaoyunhanjin1000yigeshenjingyuan,danaowangluoyichangfuza,shenjingyuanshumuzhongduo,ermeigeshenjingyuandefangdianmoshi、bianmamoshi、xinxichulifangshijunbuyiyang。suoyi,yaolijiezheigefuzadexitongruhegongzuo,shouxianxuyaonengyouduirenleidanaohuodongshujuchixujiludeshouduanhegongju。suizhekexuejieduinaodiandejilu、tiqu、fenxiheyanjiu,yuelaiyueduoduiyudanaodeshendurenzhibeiluxufaxian。

彩票平台neimezaizhongduonaobujibingli,naleinaobujibing,duicujinnaoburenzhiheleinaozhinengyanjiuzuijuqianli?

癫痫无疑是脑科学研究一个很好的模型。

彩票平台yuaercihaimo、pajinsendengtuixingxinggongnengshenjingjibingyijiyiyuzhengdengjingshenjibingbutong,zaizhongduonaobujibingdangzhong,dianxianshiyigekuazhongzu、nianlingyuxingbie,guanchuangetiquanshengmingzhouqidenaobumanxingjibing。

彩票平台daozhidianxiandebingyinduozhongduoyang,youxiantianjiyinquexian,yeyouhoutianfayu、naobuneiwaichuangshangdeng,danguijieyigehexintezhengjiluneitedingnaoqu(zhixianqu)chuxianshenjingyuantufaxingyichangfangdian,tongguoshenjingchuandaotongluchuandaozhiquannaogegegongnengqu,bingzuizhongdaozhiduanzandedanaogongnengzhangaiheshentijinengshineng。

正是由于癫痫发作特性所形成的对特定脑区短暂的功能剥夺,使人类能透过癫痫发作,借助某些特定手段(如SEEG脑电极)有效记录癫痫发作期间,异常脑电在大脑神经网络中的传导路径,以及特定脑区功能丧失前后的特征对比,癫痫每一次的发作,无疑都对人类“认知大脑”提供了极其宝贵的“深空信息”。

彩票平台ruguorenleiduiyudanaodeyanjiubeichengweishizirankexuezhongzuihouyikuaijiangyu,neimeduidianxiandeyanjiuzeshirenleitansuozuihouyipianjiangyudelubiao。ciwai,dianxianyanjiuhaijuyoushenyuandeshehuiyiyi。

shijieweishengzuzhidebaogao《dianxian: gonggongweishengdedangwuzhiji》zhongzhichudianxianshishijiezuichangjiandemanxingshenjingxitongjibingzhiyi,yingxiangquanshijiegegenianlingyue5500wanren,dianxianduiguojia、shehui、yiliaoxitong、bingrenjiatingyubingrenlaishuodoushizhangqierjudadefudan。

彩票平台zaifazhanzhongguojia,youyurenmenduidianxianquefazhengquerenshijiyiliaoziyuankuifa,daduoshudianxianhuanzhedebudaoheliyouxiaodezhiliao,cunzaihendade“zhiliaoquekou”。caipiaopingtaiguohuodongxingdianxianhuanzhedezhiliaoquekoudadao63%。jucigusuancaipiaopingtaiguodayueyou400wanzuoyouhuodongxingdianxianhuanzhemeiyoudedaohelidezhiliao。

彩票平台youqishishoushuzhiliaoshouduan,caipiaopingtaiguoyouchaoguo1000wandianxianhuanzhe,yuezhanzongrenkoude7‰zuoyou。qizhong,yue300wanhuanzheshuyuwufayikaoyaowuzhiliaoyouxiaokongzhibingqingdenanzhixingdianxian,zheipihuanzhexuyaojiezhugengweiqianyandewaikeshouduanlaifuzhuzhiliao。

jinguankangdianxianyaowudeshuliangzaiguoqu20nianlidafuzengjia,danyueyousanfenzhiyidehuanzherengranduiyaowuzhiliaochanshengkangyaoxing。suiranwaikeshoushudexiaoguoyousuogaishan,yibanyishangdeshoushuhuanzhezhangqimianyudianxianfazuo,danrengzhiyouyixiaobufennaiyaohuanzhejieshouledianxianshoushu。

AI介入癫痫初诊: 无创脑机接口信号解读有限

suirancunzaijiaodadezhiliaoquekou,dandianxianqishibingbukepa。zaixianyoudezhiliaofangfaxia, 90%dedianxianhuanzhedoushikezhiyude。congzhiyudeshouduanlaikan,60%-70%dedianxianhuanzhekeyitongguoyaowukongzhi,30%dehuanzhexuyaotongguoshoushujinxingzhiliao。

danshidianxiankezhiyu、kezhiliaobingbuyiweizhecaipiaopingtaiguodianxianzhiliaozhongbucunzaikunju。youqishizaicaipiaopingtaiguoyiliaoziyuanjinque,dianxiangengweigaofadeqingkuangzhixia。

彩票平台erxianyoudezhenliaoliuchengbunengdadaodeliefeng,zhengshiaijierushengzhangtansuonaodianyanjiudeturang。

彩票平台congdianxianzhenduanyuzhiliaodegehuanjiekan,congbinghuanchucijieshouzhenduandaodianxianquezhen,congquezhenhoudechixujiancedaodianxianchangguiyaowuzhiliaoyukongzhi,congyaowuwufakongzhisuoxingchengdenanzhixingdianxianquerendaojiezhuwaikeshouduanjieruyuzhiliao,naxiexinjishuzhengzaishentoujindianxianzheigegulaodejibingzhong,bingqiedailaiqieshidegaibian?naxiehuanjieyunhanjudatouzijiazhi?dongmaiwangduicijinxingleshuli。

caipiaopingtaikeyibaaishentoudianxianzhenliaohuanjiefenweisangejieduan: chucizhenduan、yongyaojianceheyujinghenanzhixingdianxianzhenliao

>>>>1、初次诊断和累计确诊

彩票平台zaichucizhenduanheleijiquezhenjieduan,congdianxianshouciyichangfazuodechucizhenduandaozuizhongquezhen,naodiantu(eeg)jianchashidianxianzhenduandechangguibuzhou。yibanlaishuo,tongguonaodiantujiancha,80%zuoyoudedianxianbingrenfazuojianxieqijunyounaodiantuyichang,zhiyou5%-20%dedianxianbingrenfazuojianxieqinaodiantukebiaoxianzhengchang。

>>>>临床困局1: 诊断与分流困局

gaijieduanmianlindezuidakunju,shirengongzhenliaoziyuandequefa。caipiaopingtaiguonaodianshiziyuanjinque。youyunaodianshebei、suanfaherencaidexianzhi,dianxiandezhenliaogongzuoshoudaozhuduoxianzhi。tongshi,youyuyoufengfuzhenduanjingyandenaodiantushiyushenneilinchuangyishengduojizhongzaizhongdiandianxianzhongxin,jiazhihuanzhejihuanzhejiatingjiyuduidianxianchushifazuodeweizhiyukonghuang,duoshuhuanzhejizhongyongxianggeshengshisanjiayiyuan,daozhibinghuanwufayouxiaofenliu,tongshidaliangyisidianxianbinghuanyuchufadianxianbinghuandezhunquezhenduanheyouxiaoqufenchengweilinchuangtuchunanti。

>>>>

临床困局2: 需求与供给困局。

彩票平台conglinchuangjingyankan,chucijiuzhenbingzuizhongquezhendedianxianbinghuanrenshuyuezhanzongjiuzhenbinghuanrenshude20%zuoyou,yizhongguomeinianxinzeng40wandedianxianbinghuanweijishujisuan,meinianjinshejichuzheneegjiancedezongrenshujiujiejin200wanzuoyou,haiyaojiashangyiquezhenleijidejin1000wandianxianbinghuan。

彩票平台erduichuzhenhuanzhejinxingquerenheduiquezhenhuanzhejinxingchangguieegjiance,changchangshejiduolinchuangzhongxin、duocichangguinaodiantujiance(quezhenbinghuanchangguieegyuezai2.5ci/nian),daozhiduixianyouyiliaozhenduanziyuandedaguimozhanyong,jigediyiliaotixidailaichenzhongfudan。

yibeijingmouqudianxianzhongxinweili,eegchangguijianchashulianggaoda1.5wanrenci/nian,danrenzhenduanfeiyongyuewei800yuan/ci,zhongxinpeibeichangguinaodiantujishuliangyigaoda15tai,naodiantushirenshuduoda20duoren。yinjiancerenwuguozhong,gongzuohuanjingkuzaodanyi,qieshengqianlujingxiazhai,daozhinaodiantujishiliushilvgao,zheiyoujinyibujiazhongjiuzhenbinghuanxuqiuyuyiliaogongjizhijiandemaodun。

>>>>初诊阶段产业价值及重要参与方:

巨量癫痫病患的EEG监测需求,以及EEG数据的时序性特点(阅片过程耗时漫长),高度依赖人工方式识别与输出诊断结论难以为继。在此背景下,利用AI算法快速提取关键病理性EEG脑电数据成为大趋势。

彩票平台muqian,gailingyuyijingyouzhongduokejigongsijieru,baokuoalijiankang(2019nian5yueshangxianalidianxiannaodianfenxiyinqing)zaineidezhongduoguoneiwaikejigongsijihulianwangjutoujunyijijijierudianxianzhenduanlingyu,xiwangtongguoaisuanfahuanjieyiliaozhenduanziyuanbuzudeqingkuang,zai5gxinjijiandetuidongxia,tongguoyunyiliao、yuanchengdashujudengfangshi,huanjielinchuangziyuanfenbubujundexianzhuang。

相关产业与脑科学关联度: ★★☆☆☆

彩票平台congxianyoudianxianeegnaodianaizhenduandeqiyebujulaikan,tamendoubingfeizhuanzhuyudianxianzhenliao,ershikanzhongledianxianzhenliaobeihoudenaodianyanjiujiazhi。chengran,eegnaodianjianceduiyunaodianyanjiuyouzhejudajiazhi,danmuqianyaoshixianyouxiaoliyonghaixuyaojiejuezhongduotiaozhan。

EEG脑电监测手段的出现已有悠久历史,全球各大顶级学府均已深度介入无创监测的研究,但因头皮脑电监测数据信噪比差,有效特征数据解耦困难,且受制于监测环境及个体特性等多重制约,导致脑科学界可从其中进一步挖掘更深入认知数据的难度异常巨大。

dongmaiwangcengyuzaimeijisuanshenjingkexuelingyumouxuezhecaipiaopingtai,tajiangeegnaodianjiemaguochengxingxiangbiyuwei“zhanzaijudadezuqiuchangwai,xiangqulijiehetingdongzuozaitedingquyuzuoxidemouyixieqiumizaijiaotanshenmeyiyangkunnan,xuduoshenjingyuanzaijingguochushixinhaodeouhehou,yijingxingchengjudaercaozadebeijingyin,qiexuyaoteshushijian,rumouyifangqiuduijinqiule,cainengdazhifenqinglaizinayifangqiuduideqiumidehuanhusheng,wuchuangbci(naojijiekou)lingyuzhengshiruci,gengduozhinenghuodequyudequshixinhao,wufajinyibulijiegengshendehanyi。”

无创BCI(脑机接口)信号解读有限也是为什么较多脑机接口公司扎推于浅层意念控制、睡眠等领域。在该领域创业项目多局限于尝试解读特殊脑区(运动区),以及具有显著特征的EEG脑电特征(如癫痫)的发作监测,用于无创BCI脑机接口的开发及应用。该领域更多集中在所谓“意念”控制的领域,如遥控玩具等,结合肢体与肌电反馈等,切入泛娱乐行业,国内如EEGSmarT,国外包括如Neuroverse,均为面向家用消费级及精神护理(睡眠健康)领域的创业项目。
NeuroVerse-无创BCI

彩票平台neuroverse-wuchuangbci

该领域公开过往融资的企业包括:
用药监测与预警成为AI+癫痫第二赛道

yongyaojianceyuyujingchengweiai+dianxiandiersaidao

ainenggouyiqigaoxiaochulifuzashujudetedianhuanjiedianxianchucizhenliaodegongxunanti。ranggengduohuanzhekeyihuodeyaowuzhenliao,dansuizhierlaideshiquezhenhoudeshenjingyaowuchangguizhiliaodenaiyaoxingkunju。

>>>>临床困局1: 耐药性困局 

zaidianxiandezhiliaozhong,geleidianxianyaowuzhiliaoshizhuliuzhiliaofangshi。dianxianbinghuanzaifuyaokongzhiqijian,xuyaobudingqijidingqijieshouchangguinaodianjiance,yigenzongpingguzhiliaoxiaoguojinaiyaoxing。

彩票平台duiquanqiu5500wanhuoyuexingdianxianbinghuaneryan,zhangzhouqi、chixudedianxianyongyao,huichanshengduitedingdianxianyaowuchanshengnaiyaoxing。genjulinchuangguangfantongjiyuyanjiu,linchuangshangyue30%dedianxianhuanzheyingyongkangdianxianyaowuzhiliaohoubingbunengwanquankongzhidianxiandefazuojinzhan,qizhiliaonandujiaoda,qiezhengzhuangchixushijianxiangduijiaozhang,jingyingxiangxuejianchakejianhaimayinghuadengnaobubingbian,gaibufennaiyaobinghuanduoshuhuichengweinanzhixingdianxianqunti(nanzhixingdianxianyibanzhi,shiyongliangzhongjiyishangkangdianxianleiyaowurengwufayouxiaokongzhidianxianfazuo)。

>>>>临床困局2: 癫痫看护与发作预测困局

彩票平台daliangdianxianbinghuandecunzai,jiguojia、shehui、jiating,getijundailailejudadefudan,tebieshidianxianbinghuanbenshen,yinfazuodetufahesuijixing,chengshouzhejudadexinliyali,bushaodianxianbinghuanyeyincisangshidulishenghuonengli,bufendianxianbinghuanrongrushehuidepoqiexinli,yerangxuduodianxianbinghuanzhuguanshangyinnihuanbingshi,gengshijishehuijijiatingdailaiwuxianyinhuan。

>>>>产业价值及重要参与方:

彩票平台quanqiuzhuyaoshengwuyiyaoqiye,zhangqitourujuziyanfaqiwangxingchengkegengtide,chixuyouxiaodexinxingdianxianyaowu。zaiyaowuyanfalingyu,yechuxianlejiyinliaofa,yijijiezhuxindeshouduan(rujiyinjiance)panduandianxianyuanfaleixing,gengjiadingxiangjingzhundijiejuehekongzhidianxianfazuowenti。

彩票平台2019nian2yue,chuchuanggongsiarvelle therapeuticshuo1.8yimeiyuanalunrongzi,tuijinkangdianxianjiyinzhiliaoliaofadekaifa。

针对癫痫耐药性问题,除了开发新药、新疗法等治本解决方案,实现更好的癫痫看护和发作预测也是一种缓解问题的方式。

如何解决如此庞大癫痫群体有效看护和发作预测,避免癫痫个体置身危险境地,是全球科学界、医学界以及产业界努力希望解决的难题。

彩票平台dianxianfazuoyujingkeyishixianjiancehuanzheyongyaoqingkuang;shibiedianxianfazuomoshidebianhua;lianghuadianxianfazuoshuju。bansuieegnaodianjianceshebeidexiaoxinghuahekechuandaihua,nengweidianxianfazuotigongnapa30miaozhi1fenzhongdeyujingzhouqi,yenengbangzhubinghuanjianshaohuanjingfengxianchangkou。

ciwai,dianxianbinghuanzhangzhouqiyouxiaojiance,yenengjileiduigaiquntidejiankangpingjiazhishu,duibufenqingzhengqunti,yuanyoubaoxianwufafugaiderenqun,yejiangjiezhugailuojidedaobaoxianfugaidekuozhan。muqianchuyubinghuankanhuyudianxianyujinglingyudechuangyexiangmubaokuo:

相关产业与脑科学关联度: ★★★☆☆

从切入脑科学研究的角度来看,癫痫的家中看护和预测发作用于脑科学研究还尚不成熟。

彩票平台zhuyaoyuanyinyeshishouzhiyunaogongnengshenjingkexuelingyuduidianxianfazuodicengyanjiu,rengweihuodexianzhuxingtupo,baokuokechuandaishebeidexiaoxinghuayunaodianjiancesuanfawufajiangu,yijiyanyongyuanyoueegnaodianxuyaoduiaisuanfayouxiaoxingyouyangedeyanzheng,youlaiyugengduotezhengyangbenshujujinxingsuanfaweiyang。

shangweichengshudegenbenyuanyinhaizaizaiyu,caipiaopingtaishangweihuodejiyurennaodegengweijingxide“quannaojieguanshenjinglianjietupu”,haimeiyoujiekaieegnaodiantezhengyugongnengshenjingwangluo、dianxianfazuozhijiandedicengjizhi。zhiyouzaicizhihou,cainengjiezhu5gdenggaodaikuan、diyanshideshujuchuanshushouduan,liyonggengjiaqiangdadeeegnaodianyunpingtaidesuanli,shishiwanchengdianxianbinghuanduandekuaisujianceyuyupanshuchu。

yingailingyuzhuyaochangjingzhenduifanyiliaoyijijiating,guanjianshujudehuoqurengtingliuzaibinglibingshishang、rengongganyuzhenduanyijichangguieegnaodianfenxidengyunyingleishujuheqiancengyiliaoshuju,shangweishezuyouliyunaokexuezhongdatupodeguanjianhexinshuju。

难治性癫痫,AI逐步缩小脑电未知 

彩票平台ruguoshuozaiaizaiciqianlianggehuanjiedejieru,kuodaledianxianhuanzhehuodejingzhunzhenliaodejihui,kuodaledianxianhuanzhedegongji。neimeduiyunanzhixingdianxian,aidejieruzeshitishengyiliaojigouheyishengchuliheyingduijudaxuqiudenengli。

>>>>临床困局1: 药物常规治疗手段的失效 

genjuquanqiulingyuduinanzhixingdianxiandejianyidingyi,nanzhixingdianxian(intractableepilepsy)youchengwanguxingdianxian,zhiyingyongliangzhongjiliangzhongyishangshidangdeyixiankangdianxianyaowuzhengguizhiliaoqieyaowudexuenongduzaiyouxiaofanweinei,rengwufayouxiaokongzhidianxianfazuoqieyingxiangrichangshenghuo。

彩票平台gaibufennanzhixingdianxianbinghuanquntibushaoyinzhangqifuyao,bansuidanaohexingongnengquleijinyubukenideqizhixingbingbian,daozhibufendianxianbinghuanzhubufazhanxingchengluneidanchuhuoduochu,danaodanceshenzhishuangceduojuzaozhixianqu,shiyongliangzhongjiyishangchangguikangdianxianleiyaowuyiwufayouxiaoganyuyukongzhizhixianquyichangnaodianjifa。

目前从全球范围来看,难治性癫痫占活跃性癫痫总人数的比例接近30%,在中国有近300万癫痫病患属于难治性癫痫范畴。同时每年新增新发确定约40万癫痫病患,这其中约有10万属于难治性癫痫类型。

yutongguoyaowukeyouxiaokongzhidianxianfazuodeyibanxingdianxianeryan,nanzhixingdianxianduijiating、shehuideweihaigengweijuda。ru2019nianshenzhenfashengde5·16tedajiaotongshiguzaocheng3si18shangcantongbeiju,zhengshiyoufuyaoqidianxianfazuo,nanzhixingdianxianjibaokuogaimingdianxianbinghuanzaineisigejiatingdailaiwufamibudeshanghai。ruheyouxiaohuanjiedianxianfazuo,jiangdifazuopinci,chengweizhongduolinchuangshouduanguanzhudehexinmubiao。

解决大量难治性癫痫病患诊断与治疗,成为摆在脑科学与临床界的一道必须攻破的难题。

>>>>临床困局2: 难治性癫痫治疗手段有限

从难治性癫痫诊断与治疗方式来看,神经外科手术介入是目前推动的重点方向。

shenwaishoushucongjiejuenanzhixingdianxiandegenyuanchufa,shenjingwaikeyishengzaiqiechuzhidianquzhiqian,xuyaotongguozhirunaoneidianji,liyongseegluneilitidingxiangjishumingquedanaozhongdezhidianqu。ranhoujuedingshijinyibucaiqubaokuoshoushuqiechu、shepinxiaorongyujiguanghuisundengzhijiehuisunzhixianzaodetichushouduan,haishixuanzebaokuodbs、vns、rnsdengyixilieshenjingdiaokongjishuzaineide,zuoyongyuduiyingnaoquzhudongganyudianxianzhixianzaodeyichangfangdiandeguxixingzhiliaofangshi。

zi2000nianqi, seegzaibeimeinanzhixingdianxianzhiliaozhongtuiguangbingguangfanyingyong。zuixintongjibiaoming,seegyijingchengweizuizhongyaodeluneijianceshouduan(zhansuoyouluneijiancede43.1%),zuoweigaixiangjishufayuanguodefaguo,zhenduidianxianwaikeshoushuqianzhixingshoushudeseegshiyongbiliyijinggaoda60%yishang。zhongguomuqianseegshoushudeshishibilizhannanzhixingdianxianwaikeshoushudebili,yecongzhiqianbuzu5%kuaisutishengzhimuqiande25%zuoyou,yuseegjishuyichengshudeoumeiguojiaxiangbi,rengranyunhanzhejudadezengzhangkongjian。

彩票平台zuoweiquanmeizuizhimingdemeiaoyixuezhongxin(mayo clinic),ziyinrudianxianwaikeshoushuyilai,dianxianzhongxinshuliangcongyuanyoude14gezengjiazhimuqiande94ge,qizhongchengrenzhongxincong2003niande14gezengzhi2012niande66ge,ertongzhongxincong2003niande3gezengzhi2012niande28ge。congshujukeyikanchu,dianxianwaikeshoushuzhiliaodeyouxiaoxing,jidadetuidongledianxianzhongxindecaipiaopingtai。

zaizhongguo,jiyuzhiliaomudededianxianwaikeshoushu,yezaiguoqu5niandedaofeisufazhan。genjuzhongguokangdianxianxiehuiyifenshujubiaoming,jubuwanquantongji,quanguodianxianwaikeshoushuliangyicong2015nian4000taizuoyou,zengzhangzhi2018nianjin20000tai,erzuoweishishidianxianwaikeshoushuzhiguanzhongyaodeshuqianseegluneishenbudianjijiancejishu,zi2013nianqianhouyouguoneizhumingshenjingkexueshudaitourenzhiyideliuxingzhoujiaoshouyinruzhongguoyilaiyeguangfanpujikailai,cong2014niandebuzubaitai,xunsuzengzhangzhi2019niandejin5000tai,qizhongnengshishiseegshoushudedianxianzhongxincong2014niande6jiazengzhangzhi2019niandejin200jia。

彩票平台dianxianshoushuzhongzuizhuyao、yeshizuihexindelinchuangjiazhizaiyu,nengfouzhunquechazhaojiyouxiaomingquedianxianzhibingzao,yijijiedingzhixianzaoyuzhouweizhengchanggongnengnaoquzhijiandeshenjingwangluolianxi,yezhiyouzheiyangyigeqianti,cainengzuidaxiandujiezhuwaikeshoushufangshi“tichu”zhixianquduizhoubianzhengchangnaogongnengdeyingxiang。

zheilijieyonglinchuangjiemoushenwaijiaoshoudebiyu,“dianxianmeiyicidefazuo,jiuxiangzaiguangmodecaoyuanliranqixiongxiongliehuo,zhixianqujiushiqihuodian。zuiyouxiaokongzhidahuomanyandefangshi,jiushigejuedahuoqiyuandianyuzhoubiancaoyuandelianxi。”

>>>>产业价值及重要参与方:

nanzhixingdianxianzuoweiyigejianshenhegaobileidelingyu,shoudaodechanyeguanzhubingbushao。muqian,guoneiyiyouzhongduochanyefangqierudianxiangongnengshenwailingyu。

zaidianxianzhenduanhezhiliaodechanyelianzhong,jibaokuoleyanfadaxingyiliaoshebeidequanqiuzhimingyiliaojituan,runigaoli、ribenguangdian、ge、feilipu。yebaokuoyanfashoushujiqiren、aifuzhuzhenduandengchuangxinxingdejiejuefangan。

muqian,guoneiyiyoubaokuohuakejingzhun、ruimi、huazhiweichuangdengguoneizhiminggongnengshenwaishoushujiqirenwanchengbuju。zaishoushugaozhihaocaifangmian,youbaokuohuakehengsheng、nuoeryiliao、ruishenanzaineideyiliaoqixieshang,xingchengduialics,pmt,adtechdenghaiwaijinkoudianji(sanleigaozhihaocai)dejinkoutidai。

彩票平台jubuwanquantongji,zuoweiquanqiunaodiantujilingyuzhimingchangshangderibenguangdianjimeiguonigaoli,weimanzuguoneidaliangsanjiayiyuancaipiaopingtaidianxianwaikezhongxindexuqiu,guoquliangnianzaizhongguoshichangxintoufangdegaodaoliannaodiantujishuliangleijichaoguo300taiyishang,ergouzhizheixiezhuanyongyuseegdianjide128-256tongdaogaodaoliannaodiantuji,yeshizuodianxianwaikeshoushunenglizhishuzengzhangdeqianzhixingzhibiao。

ciwai,zuoweikuaisutishengshoushuxiaolvdeshenwaijiqiren,zaiguoquliangnianliyechuyukuaisushangyehuadejieduan。chuguojizhimingpinpairosashenwaijiqirenyiwai,guoneibaokuohuakejingzhun、ruimi、huazhiweichuangdengyipijuyouzizhuzhishichanquandeshenwaijiqiren,yezaiguoquliangnianlipiliangtoufanglinchuangshiyong,jubuwanquantongji,jiezhi2019niandi,yishangshenwaishoushujiqirenchangshang,zaiguoneileijitoufangshebeishuyichaoguo150tai。

以上大量新建癫痫中心的出现,SEEG等关键临床手段的普及推广,以及高导联脑电图机、神外手术机器人等关键设备的持续大规模投放,也侧面反映出不少具有敏锐商业嗅觉的全球VC及产业资本,正积极布局至具有5500万病患的癫痫产业,以满足飞速增长的癫痫诊疗需求。
癫痫诊断与治疗上下游全景图

彩票平台dianxianzhenduanyuzhiliaoshangxiayouquanjingtu

彩票平台zainanzhixingdianxianzhiliaozheigexiaozhongdelingyu,butongdeqierufangxiangyaojiejuedewentibingbutong。shoushujiqirendadaditigaoleshoushudejingzhunduhexiaolv;cigongzhenjianrongdenaoneidianjirangyishengkeyijingzhundingweizhidianquweizhidengdeng

但从解决临床核心痛点而言,关键点还是在于如何快速精准识别和分析SEEG深部脑电,以及多模态融合算法形成颅内3D影像与SEEG脑电耦合并输出精确癫痫致痫灶以及深刻理解癫痫异构网络模型。

以下这张诊断治疗周期图,也能体现难治性癫痫诊断环节的重要性:
基于SEEG手术方式的难治性癫痫诊断与治疗

jiyuseegshoushufangshidenanzhixingdianxianzhenduanyuzhiliao

congtuzhongkeyimingque,seegshoushushuhoudezhencezhouqishizuiweihaoshidehuanjie。tongshi,caipiaopingtaihaikeyiyujian,suizheshenwaishoushujiqiren、guanjianlinchuangqixiegongnengdiedai(ruseegdianji3.0tcigongzhenjianrong)、seegnaodiantuaifuzhujuecedengchanpinhejishudetuiguang,nanzhixingdianxianzhenliaoxiaolvjiangconggegehuanjiededaotisheng,weilaiguoneiseegshoushushuliangjianghuikuaisukuozeng。

例如,彩票平台注意到公开报道的诺尔医疗,除了布局术中高值耗材SEEG脑电极外,还向下游拓展,在AI辅助识别和分析SEEG脑电信号领域也有深入布局。

相关产业与脑科学关联度: ★★★★★☆

congshangmianzheizhangtucaipiaopingtaixiangxin,bansui5g、dashuju、aijishudeguangfanyingyong,zaidianxiantebieshinanzhixingdianxianlingyujiangyoujihuichuxian“huangjingu”,laizinaobushenbudenaodianxinxihuoxunenggouchengweitansuohedakainaobuyanjiudeyibayaochi,bangzhukexuejiagenghaodirenzhidanao。

jinliangnianlai,《science》、《natural》denghexinzhimingqikanyechuxianduopianyiseegshenbunaodianzuoweiqierudian,duinaobujichurenzhijinxingyanjiudechengguo。

彩票平台或许可以这样认为SEEG脑电极作为“宇宙深空探测器”负责记录大量深脑信息,再由有经验的宇宙物理学家们(神外科学家们)去解读大脑其中的奥秘。

zaiyunaokexuelingyuneiyixiezhuanjiacaipiaopingtaiguochengzhong,caipiaopingtaiguanzhudao,nanzhixingdianxianzaizhenduanyuzhiliaoguochengzhong,liyongseegshennaodianji,nenghuodedaguimoxiquedeshenbunaodianshuju,jinnianlai,quanqiuzhongduodingjikeyanjigoukaishijiezhuzheixiezhenguixinxi,xingchengduidanaodegengweiquanjuderenzhi,caipiaopingtaichangshiyizhongguonaojihua“yitiliangyi”deshijiao,yongxiamianzheizhangtuzhanshiseegshenbunaodianduirenzhinao、baohunaoyijichuangzaonaosuoqidaodezhongyaozuoyong:

从这张图彩票平台能更加全景的理解到,通过癫痫诊断过程,特别是SEEG手术逻辑的介入,利用fMRI、PET、CT等影像设备,形成对大脑3D影像,借助SEEG电极所获得并记录下的特定区域神经元簇群所释放的深部脑电(如pHFO高频小波),形成对于大脑功能区域脑网络的拓扑结构认知,即利用时域、频域与空间分布之间的信息耦合,而这一过程恰恰可以用于脑功能网络图谱的绘制。

彩票平台eryaoshixianhuizhipumumingyuanshisuomiaoshude‘quannaogongnengtupu’zheiyizhongyaomubiao,zhengshijiezhuyudianxianfazuoguochengzhong,bianbuyudanaoduoda200duogeseegdianjijidian(iot),jiludianxianjifataixiadenaodianchuanboxiaoying,bingzuizhonghuodedaliangzhenguirenzhishuju。

dongmaiwangyejiangchixuguanzhunaokexuelingyudejinzhan,zhuizongnaokexuelingyutupo,zuoweidakairennaoheihedeyibayaochi,seegshoushuzaiguoneikaizhanqingkuangruhe,shennaoshujuruhenengdailaidianxianlingyukuashidaidebianhua,dongmaiwangjiangchixuguanzhubaodao。suizheshenduxuexi、rengongzhinenghedailailexindeshujusoujihechuligongju,caipiaopingtaixiwangseegshennaoshujunenggoutuidongdianxianlingyuzhenliaojishuqianjinhejinyibutansuonaodianshijie,huoxushenjingkexuelingyuqudeshizhixingtupojiuzaibuyuandeweilai。

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